The latest research progress of less invasive surfactant administration and intubation-surfactant-extubation technology in the treatment of neonatal respiratory distress syndrome
10.3760/cma.j.issn.1673-4912.2025.09.010
- VernacularTitle:低侵入性表面活性物质给药技术与气管插管-肺表面活性物质-拔管技术在新生儿呼吸窘迫综合征治疗中的研究进展
- Author:
Biao WEI
1
;
Jing LI
Author Information
1. 山东第一医科大学（山东省医学科学院）研究生部，济南 250117
- Publication Type:Journal Article
- Keywords:
Less invasive surfactant administration;
Intubation-surfactant-extubation;
Neonatal respiratory distress syndrome;
Premature birth;
Ventilator-induced lun
- From:
Chinese Pediatric Emergency Medicine
2025;32(9):690-694
- CountryChina
- Language:Chinese
-
Abstract:
Surfactants are the cornerstone of treatment for neonatal respiratory distress syndrome (NRDS).In recent years,with the continuous development and popularization of minimally invasive techniques and related concepts,less traumatic administration methods such as less invasive surfactant administration (LISA) have been proposed.Although LISA technology has become the mainstream solution for the prevention and treatment of NRDS in regions such as Europe,the pathophysiological mechanisms underlying its potential clinical advantages have not yet been fully elucidated.This article reviewed the differences in efficacy between LISA and the intubation-surfactant-extubation technique in the treatment of NRDS,the unique advantages of LISA,and its pathophysiological basis,providing a theoretical rationale for optimizing neonatal respiratory support strategies.
