Research progress in mitochondrial regulation of osteogenic and odontogenic differentiation of dental-derived mesenchymal stem cells
10.3760/cma.j.cn112144-20250116-00022
- VernacularTitle:线粒体调控牙源性间充质干细胞成骨及成牙分化的研究进展
- Author:
Lijie WANG
1
;
Jian ZHOU
;
Chenchen ZHOU
Author Information
1. 四川大学华西口腔医院儿童口腔科 口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心，成都 610041
- Publication Type:Journal Article
- Keywords:
Mitochondrial;
Dental-derived mesenchymal stem cells;
Osteogenic differentiation;
Odontogenic differentiation;
Oral tissue regeneration
- From:
Chinese Journal of Stomatology
2025;60(6):662-668
- CountryChina
- Language:Chinese
-
Abstract:
Dental-derived mesenchymal stem cells (DMSC), owing to their self-renewal capacity and multi-lineage differentiation potential, have demonstrated significant promise in the field of oral tissue regeneration. Mitochondria, as essential organelles within cells, can not only be responsible for energy metabolism but also influence the maintenance of stem cell stemness and the direction of differentiation by regulating cellular metabolic processes, apoptosis, and signal transduction pathways. In recent years, the mechanisms by which mitochondria participating in the osteogenic and odontogenic differentiation of DMSC have gradually become a research focus. This paper reviews the regulatory mechanisms of mitochondria in the osteogenic and odontogenic differentiation of DMSC, with emphasis on how mitochondrial energy metabolism (oxidative phosphorylation and glycolysis) and quality control processes (namely biogenesis, dynamics as fission and fusion, and autophagy) modulate the differentiation of DMSC. The aim is to provide a theoretical basis and reference for the research and application of dental pulp regeneration, periodontal tissue regeneration, and other aspects of oral tissue engineering.
