Recent advances in the relationship and mechanistic study of hyperglycemia and oral potentially malignant disorders
10.3760/cma.j.cn112144-20241105-00416
- VernacularTitle:高血糖与口腔潜在恶性疾患的相关性及其机制的研究进展
- Author:
Yuqi LUO
1
;
Haifen FENG
1
;
Yidi ZHANG
1
;
Xiaobo LUO
1
;
Qianming CHEN
1
Author Information
1. 四川大学华西口腔医院口腔黏膜病科 口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心 中国医学科学院口腔黏膜癌变与防治创新单元，成都 610041
- Publication Type:Journal Article
- Keywords:
Mouth mucosa;
Oral potentially malignant disorders;
Hyperglycemia;
Diabetes mellitus;
Malignant transformation;
Reactive oxygen species;
Epidermal growth fa
- From:
Chinese Journal of Stomatology
2025;60(7):793-799
- CountryChina
- Language:Chinese
-
Abstract:
Oral potentially malignant disorders (OPMD) refer to a group of diseases occurring on the oral mucosa that harbor the potential to progress into oral squamous cell carcinoma, including oral leukoplakia, oral erythroplakia, discoid lupus erythematosus of the oral mucosa, oral submucous fibrosis, oral lichen planus, actinic cheilitis, etc. Diabetes mellitus (DM) is one type of diseases characterized by chronic hyperglycemia, with a high incidence and mortality rate worldwide. Hyperglycemia is the characteristic metabolic change in DM patients and those in the pre-diabetic stage, playing a determinative role in many complications related to DM. A number of clinical studies had revealed an association between hyperglycemia and OPMD, as well as its malignant transformation. This article will review the potential regulatory effects and mechanisms of high glucose states, such as diabetes, on OPMD, and assess the correlation between hyperglycemia and the malignant transformation of OPMD.
