Advances on B-cell targeted therapy in childhood-onset systemic lupus erythematosus
10.3760/cma.j.issn.1673-4912.2025.06.003
- VernacularTitle:B细胞靶向治疗在儿童系统性红斑狼疮中的应用新进展
- Author:
Peng ZHOU
1
;
Yue DU
1
;
Yubin WU
1
Author Information
1. 中国医科大学附属盛京医院小儿肾脏风湿免疫内科,沈阳 110004
- Publication Type:Journal Article
- Keywords:
Targeted B-cell therapy;
Systemic lupus erythematosus;
Children
- From:
Chinese Pediatric Emergency Medicine
2025;32(6):413-417
- CountryChina
- Language:Chinese
-
Abstract:
Systemic lupus erythematosus is a chronic autoimmune disease. Childhood systemic lupus erythematosus has complex pathogenesis,more severe tissue damage,and higher involvement rates of kidneys and other systems. The treatment goals are to reduce damage and prevent recurrence. B cells play a key role in its pathogenesis,making B-cell-targeted therapy a focus. Various drugs like Rituximab,Belimumab,Obinutuzumab,Telitacicept,and chimeric antigen receptor T-cell therapy have been used. Although each shows efficacy,long-term safety needs research. In the future,precise individualized treatment based on biomarkers is expected.
