Effects of early vitamin D supplementation on immunoglobulin, T cell subsets, serum interleukin-1β and interleukin-10 levels in premature infants
10.3760/cma.j.cn115455-20230811-00107
- VernacularTitle:早期补充维生素D对早产儿免疫球蛋白、T细胞亚群及血清白细胞介素-1β、白细胞介素-10水平的影响
- Author:
Rui ZHANG
1
;
Yue SUN
;
Na LI
Author Information
1. 河北省沧州中西医结合医院新生儿科，沧州 061000
- Publication Type:Journal Article
- Keywords:
Infant, premature;
Vitamin D;
Immunoglobulins;
T-lymphocytes;
Interleukins
- From:
Chinese Journal of Postgraduates of Medicine
2025;48(2):102-105
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of early vitamin D supplementation on the immune function of premature infants.Methods:A total of 150 premature infants admitted to Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from January 2022 to March 2023 were enrolled perspectively, they were divided into the intervention group (75 cases) and the control group (75 cases) by the random number table method. The control group received formula milk intervention, and the intervention group received early vitamin D supplementation treatment on the basis of the control group. The course of treatment was 14 d. The levels of serum 25-hydroxyvitamin D [25- (OH) D], immunoglobulin (Ig), T cell subsets, complement C3, C4, and serum interleukin (IL)-1β and IL-10 were compared between the two groups before and after intervention.Results:The level of serum 25- (OH) D in the intervention group at 14 d after intervention was higher than that in the control group, the level of IL-1β was lower than that in the control group: (30.13 ± 6.00) nmol/L vs. (26.84 ± 5.79) nmol/L, (0.54 ± 0.20) ng/L vs. (0.65 ± 0.23) ng/L, there were statistical differences ( P<0.05). The levels of CD 3+, CD 4+, complement C3, C4, and IL-10 in the intervention group were higher than those in the control group at 14 d after intervention: 0.692 ± 0.043 vs. 0.632 ± 0.038, 0.400 ± 0.027 vs. 0.369 ± 0.026, (0.98 ± 0.26) g/L vs. (0.84 ± 0.24) g/L, (0.20 ± 0.05) g/L vs. (0.16 ± 0.04) g/L, (13.82 ± 3.64) ng/L vs. (11.36 ± 2.93) ng/L, there were statistical differences ( P<0.05). There were no statistically significant differences in the levels of IgA, IgM and IgG between the two groups before and after intervention ( P>0.05). Conclusions:Early vitamin D supplementation can significantly improve T cell subsets and regulate IL-1β/IL-10 levels in premature infants.
