The prognostic value of serum homocysteine, neutrophil to lymphocyte ratio and total imaging load score on cognition disorders in small cerebral vascular disease patients
10.3760/cma.j.cn115455-20240909-00779
- VernacularTitle:血清同型半胱氨酸、中性粒细胞与淋巴细胞比值及影像学总负荷评分对脑小血管病患者认知障碍的预测价值
- Author:
Yunpeng SONG
1
;
Donghong GUO
;
Minxia LI
Author Information
1. 山西省洪洞县人民医院神经内科，临汾 041600
- Publication Type:Journal Article
- Keywords:
Cognition disorders;
Cerebral small vascular disease;
Homocysteine;
Neutrophil to lymphocyte ratio;
Total imaging burden score
- From:
Chinese Journal of Postgraduates of Medicine
2025;48(12):1103-1107
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the predictive value of serum homocysteine (Hcy), neutrophil to lymphocyte ratio (NLR) and total imaging load score on cognition disorders in patients with small cerebral vascular disease (CSVD).Methods:A total of 106 CSVD patients treated in Shanxi Hongdong County People's Hospital from June 2021 to June 2024 were retrospectively selected as the study objects. The Montreal Cognitive Assessment Scale (MoCA) was used to assess cognitive function. Among them, 43 patients with cognition disorders and 63 patients without cognition disorders were evaluated. Another 30 healthy subjects over 60 years old were selected as control group. General data and serum Hcy, NLR and other indicators of the three groups were compared, MRI examination was performed, and the total imaging load score was calculated. Logistic regression was used to analyze the risk factors of cognition disorders in CSVD patients, and receiver operating characteristic (ROC) curve was used to analyze the predictive value of Hcy, NLR and radiographic total load score for cognition disorders in CSVD patients.Results:The levels of Hcy, NLR and total imaging load scores in the CSVD group were higher than those in the CSVD group and the control group : (20.32 ± 3.24) μmol/L vs. (17.75 ± 2.81), (14.96 ± 3.84) μmol/L; 2.77 ± 0.75 vs. 2.27 ± 0.68, 1.93 ± 0.47; (1.28 ± 0.73) scores vs. (0.92 ± 0.55), (0.36 ± 0.21) scores, there were statistical differences ( P<0.05). The results of Logistic regression showed that Hcy, NLR and total load score were risk factors for cognition disorders ( P<0.05). The results of ROC curve showed that the area under the curve (AUC) of Hcy, NLR, total imaging load score combined prediction of cognition disorders was 0.798. Conclusions:Hcy, NLR and total imaging load score are risk factors for cognition disorders in CSVD, and have certain predictive value for cognition disorders.
