Role of periepithelial microenvironment changes in the malignant transformation of oral potential malignant disorders
10.3760/cma.j.cn112144-20241214-00481
- VernacularTitle:上皮周微环境改变在口腔潜在恶性疾患恶变中的作用
- Author:
Ying CHEN
1
;
Chao LOU
1
Author Information
1. 上海交通大学医学院附属第九人民医院口腔颌面头颈肿瘤科 上海交通大学口腔医学院 国家口腔医学中心 国家口腔疾病临床医学研究中心 上海市口腔医学重点实验室 上海市口腔医学研究所，上海 200011
- Publication Type:Journal Article
- Keywords:
Mouth mucosa;
Cellular microenvironment;
Oral potential malignant disorders;
Oral cancer;
Cancer immunology
- From:
Chinese Journal of Stomatology
2025;60(3):287-295
- CountryChina
- Language:Chinese
-
Abstract:
Oral potential malignant disorders (OPMDs) are a group of oral mucosal lesions with a risk of cancer transformation. The microenvironment surrounding the epithelial tissue is closely related to the malignant transformation of OPMDs. However, the changes and role of the periepithelial microenvironment during the malignant progression of OPMDs are not yet fully understood. This review discuss the impact of changes in the periepithelial microenvironment on the malignant transformation of OPMDs from following aspects: the immune microenvironment, stromal microenvironment, metabolic microenvironment, and oral microorganism. In the immune microenvironment, the immune surveillance capacity of periepithelial immune cells weakens, and some of these cells interact with malignant cells, resulting in an immunosuppressive microenvironment. Cells in the matrix promote the malignant transformation of OPMDs through the secretion of cytokines and nutritional support, along with extracellular matrix degradation and local angiogenesis. Epithelial cells undergo metabolic reprogramming during malignant transformation, while the resulting hypoxic microenvironment can further promote the malignant transition of epithelial cells. Oral microorganism fosters the malignant transformation of OPMDs by inducing inflammatory responses and creating hypoxic conditions.
