Progress on the application of polypeptide hydrogels in drug sustained/controlled release
10.3760/cma.j.cn112144-20241113-00428
- VernacularTitle:多肽水凝胶在药物缓释或控释中的应用研究进展
- Author:
Xuerong FANG
1
;
Huiru ZOU
1
Author Information
1. 天津市口腔医院中心实验室 南开大学医学院 天津市口腔功能重建重点实验室，天津 300041
- Publication Type:Journal Article
- Keywords:
Hydrogels;
Peptides;
Drug delivery systems;
Peptide hydrogel;
Sustained release;
Controlled release
- From:
Chinese Journal of Stomatology
2025;60(1):94-100
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, peptide hydrogels have garnered significant attention in the biomedical field due to their excellent biocompatibility, biodegradability, and low cytotoxicity. They can mimic the microenvironment of the extracellular matrix, effectively encapsulate drugs, and achieve sustained or controlled drug release, thereby facilitate tissue regeneration. This article introduces the research progress in the application of peptide hydrogels for drug sustained/controlled release. It summarizes the research hotspots in the selection and design principles of peptides, optimization strategies for peptide concentrations, and hydrogel construction techniques. Furthermore, the principles and mechanisms underlying the sustained/controlled drug release from polypeptide hydrogels are elucidated, and the detection methods applicable to different sustained/controlled release systems are summarized. The article also prospects the application potential of peptide hydrogels in the field of drug delivery and offers insights for subsequent in-depth research.
