Correlation between bone metabolism index β-CTX and metabolic dysfunction-associated fatty liver disease in menopausal women with type 2 diabetes mellitus
10.3760/cma.j.cn115624-20250214-00120
- VernacularTitle:2型糖尿病女性患者绝经后骨代谢指标β-CTX与代谢相关脂肪性肝病的相关性
- Author:
Jinchang LIU
1
;
Zhitong LI
1
;
Junwei WANG
1
;
Shiwei LIU
1
Author Information
1. 山西医科大学第三医院（山西白求恩医院 山西医学科学院 同济山西医院）内分泌科，太原 030032
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, type 2;
Metabolic dysfunction-associated fatty liver disease;
Bone metabolism;
β-C-terminal telopeptide of type-Ⅰ collagen;
Postmenopau
- From:
Chinese Journal of Health Management
2025;19(10):830-835
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation between bone metabolism marker β-CTX and metabolic dysfunction-associated fatty liver disease (MAFLD) in postmenopausal women with type 2 diabetes mellitus (T2DM).Methods:In this retrospective cohort study, a total of 279 postmenopausal women with T2DM who were admitted to the Endocrinology Department of Shanxi Bethune Hospital from February 2023 to February 2024 were included. Among them, 152 patients had MAFLD. The bone metabolism markers were measured in all the subjects. The logistic regression analysis was used to assess the correlation between β-CTX and the risk of MAFLD.Results:In postmenopausal T2DM women, serum β-CTX level in the MAFLD group [352.50 (248.60, 442.95)pg/ml ] was significantly lower than that in the non-MAFLD group [643.20 (446.10, 781.90) pg/ml]( Z=-10.896, P0.05). Binary logistic regression analysis revealed that reduced β-CTX( OR=0.986, 95% CI:0.981-0.991), BMI( OR=1.232, 95% CI: 1.046-1.451) and fasting insulin (FINS)( OR=1.155, 95% CI: 1.041-1.281) were independent risk factors for the risk of MAFLD in postmenopausal T2DM women (all P0.05), and β-CTX was negatively correlated with the occurrence of MAFLD ( β=-0.013, P0.001). Additionally, in postmenopausal T2DM women with MAFLD, serum β-CTX level was significantly negatively correlated with BMI ( r=-0.191) and TG ( r=-0.128) (both P0.05). Conclusions:The bone metabolism index β-CTX in postmenopausal women with T2DM is significantly negatively correlated with the risk of MAFLD.
