Research progress on the role of exosomes in odontogenic differentiation
10.3760/cma.j.cn112144-20240820-00317
- VernacularTitle:外泌体在细胞成牙本质分化中作用的研究进展
- Author:
Guihuai PENG
1
;
Huiru ZOU
1
Author Information
1. 天津市口腔医院中心实验室 南开大学医学院 天津市口腔功能重建实验室，天津 300041
- Publication Type:Journal Article
- Keywords:
Cell communication;
Exosomes;
Odontogenic differentiation;
Synergistic effect;
Multifactorial regulation;
Tissue engineering
- From:
Chinese Journal of Stomatology
2025;60(4):437-442
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes, serving as nanoscale molecular signals for intercellular communication, possess the ability to induce odontogenic differentiation and to promote pulp regeneration. Research on their roles in cell differentiation induction has gradually emerged as a research hotspot in the field of regenerative oral medicine. The diversity in cellular sources and pretreatment methods can influence the biological properties and functions of exosomes, while the selection of combined factors and optimization of scaffold delivery strategies further regulate the efficacy of exosomes during differentiation induction. In light of this, the present article aims to comprehensively review and delve into the multi-factorial regulatory mechanisms of exosomes in facilitating odontoblastic differentiation, aiming to provide valuable insights for the development of strategies in oral tissue engineering and regenerative therapies.
