Single-cell spatiotemporal atlas of tooth development: progress and prospects
10.3760/cma.j.cn112144-20241010-00377
- VernacularTitle:牙发育的单细胞时空图谱
- Author:
Xuechun LI
1
;
Xiaoshan WU
1
Author Information
1. 中南大学湘雅医院口腔医学中心 口腔颌面部发育与再生研究中心 中南大学口腔颌面再生王松灵院士工作站，长沙 410008
- Publication Type:Journal Article
- Keywords:
Genomics;
Tooth development;
Single-cell RNA sequencing;
Spatial transcriptome
- From:
Chinese Journal of Stomatology
2025;60(1):26-32
- CountryChina
- Language:Chinese
-
Abstract:
Single-cell and spatial multi-omics technologies enable the simultaneous analysis of thousands of cells in various states, revealing their transcriptional profiles, chromatin accessibility, and spatial positioning. Recent advances in single-cell multi-omics have led to significant discoveries regarding the definition, function, evolution, and interaction of various cell subtypes during tooth development. We summarize key findings from recent single-cell multi-omics studies on tooth development, highlighting their contributions to the field and discussing future perspectives in dental developmental genomics research.
