Exploring the clinical application effects of two different sources of domestic oral restoration membrane in guided bone regeneration during dental implantation in diabetic patients
10.3760/cma.j.cn112144-20240721-00281
- VernacularTitle:两种国产口腔生物膜在糖尿病患者单牙种植引导性骨组织再生中的骨增量效果初探
- Author:
Jing LI
1
;
Yan DONG
1
;
Fu WANG
1
;
Kehui XU
1
;
Chenyu WANG
1
;
Li CHEN
1
;
Lina NIU
1
Author Information
1. 第四军医大学口腔医院口腔修复科 口颌系统重建与再生全国重点实验室 国家口腔疾病临床医学研究中心 陕西省口腔医学重点实验室，西安 710032
- Publication Type:Journal Article
- Keywords:
Dental implantation;
Diabetes mellitus;
Collagen membrane;
Guided bone regeneration
- From:
Chinese Journal of Stomatology
2025;60(2):116-122
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the bone augmentation effects of domestic decellularized porcine small intestinal submucosa (PSIS) absorbable biomembrane and domestic bovine pericardium tissue (BPT) absorbable biomembrane in guided bone regeneration (GBR) for single-tooth implantation in diabetic patients.Methods:A prospective case-control study was conducted with 48 diabetic patients who received single-tooth implant restoration at the Department of Prosthodontics, School of Stomatology. The Fourth Military Medical University, between January 2023 and January 2024. Patients were randomly assigned to the study group (PSIS group) and the control group (BPT group) using a random number table, with 24 patients in each group. GBR was performed simultaneously with the implant surgery. Cone-beam CT was used to compare the buccal-side horizontal bone gain at 6 months post-operation between the two groups. Wound healing was evaluated at 1 and 4 weeks post-operation using wound healing scores.Results:At 6 months post-operation, the buccal-side horizontal bone gain at 2 mm below the implant abutment in the study group [69.1 (55.2, 82.4) mm] and the control group [71.4 (59.8, 77.0) mm] showed no statistically significant difference ( Z=-0.25, P=0.805). The wound healing scores at 1 and 4 weeks post-operation in the study group did not differ significantly from those in the control group at the same time points (1 week: Z=-0.49, P=0.627; 4 weeks: Z=-0.61, P=0.539). Conclusions:The use of two types of domestic absorbable collagen membranes for GBR in single-tooth implantation in diabetic patients showed comparable buccal-side horizontal bone gain effects at 6 months post-operation and similar clinical outcomes for wound healing at 1 and 4 weeks post-operation in both groups. The GBR effects of PSIS and BPT are similar.
