Cutaneous alternariosis caused by Alternaria alternata with special morphology: a case report
10.35541/cjd.20230278
- VernacularTitle:特殊形态的互隔链格孢引起皮肤链格孢病1例
- Author:
Rong LIU
1
;
Yanyang GUO
;
Jixin GAO
;
Gang WANG
;
Meng FU
Author Information
1. 西安医学院，西安 710068
- Publication Type:Journal Article
- Keywords:
Alternariosis;
Alternaria alternata;
Meristematic growth;
Ultrastructure;
Animal experimentation
- From:
Chinese Journal of Dermatology
2025;58(3):245-249
- CountryChina
- Language:Chinese
-
Abstract:
A 58-year-old female patient presented with red papules, plaques, and scabs on her right foot accompanied by pain and itching for 14 years. Dermatological examination revealed extensive red plaques on her right foot and ankle, with scattered red papules in between; some of the plaques were covered with a moderate amount of yellow-brown crusts, and a small amount of yellow exudate was observed at the junction of the toes and the dorsum of the foot. Histopathological examination of the skin lesions showed hyperkeratosis, parakeratosis, pseudoepitheliomatous hyperplasia, neutrophil aggregation in the epidermis, and mixed inflammatory cell infiltration in the dermis. Three different types of colonies were cultured from the skin lesion tissues: light brown granular colonies, black granular colonies, and white-brown filamentous colonies. Under the microscope, the filamentous colonies appeared as long chains of brown conidia with short cylindrical beaks, while the black and light brown granular colonies appeared as clusters of spores, with single or multiple septa inside, and some budding spores were observed. Electron microscopy further confirmed the above structures. Molecular biological analysis revealed that the three types of colonies were all identified as Alternaria alternata. The patient was diagnosed with cutaneous alternariosis caused by Alternaria alternata with special morphology. After 7 months of treatment with oral itraconazole, the skin lesions healed, and no recurrence was observed during a 3-year follow-up.
