Regulation of signaling pathways related to systemic scleroderma fibrosis by microRNAs
10.35541/cjd.20230730
- VernacularTitle:微小RNA调控系统性硬皮病纤维化相关信号通路的研究进展
- Author:
Jingwei XU
1
;
Shuang CHEN
;
Kelei GUO
;
Li HAN
;
Hua BIAN
Author Information
1. 河南中医药大学骨伤学院，郑州 450000
- Publication Type:Journal Article
- Keywords:
Scleroderma, systemic;
MicroRNAs;
Signal transduction;
Fibroblasts
- From:
Chinese Journal of Dermatology
2025;58(8):788-793
- CountryChina
- Language:Chinese
-
Abstract:
Systemic scleroderma (SSc) is a fibrotic disease involving the skin and a variety of internal organs, which is currently thought to be mainly caused by abnormal activation of fibroblasts and excessive secretion of extracellular matrix. Growing evidence has shown signaling cascades associated with SSc fibrosis, including transforming growth factor-β/Smads, Notch, Wnt/β-catenin, rat sarcoma/extracellular regulated protein kinases, etc. MicroRNAs participate in the post-transcriptional regulation of different target genes and control the cell state, determining the changes in transcriptomes and proteomes caused by various cellular signaling cascades. This review summarizes recent research progress in the regulatory role of microRNAs in SSc fibrosis-related signaling pathways and potential therapeutic targets.
