Role of thyroid peroxidase autoantibody in the comorbidities of pemphigus vulgaris and Hashimoto thyroiditis
10.3760/cma.j.cn112144-20240708-00261
- VernacularTitle:甲状腺过氧化物酶自身抗体在寻常型天疱疮与桥本甲状腺炎共病中的作用研究
- Author:
Lihao CHEN
1
;
Lijuan ZHANG
;
Yanxin ZHANG
;
Jing SHI
Author Information
1. 山西医科大学口腔医学院·口腔医院口腔内科，太原 030001
- Publication Type:Journal Article
- Keywords:
Pemphigus;
Thyroiditis;
Pemphigus vulgaris;
Hashimoto thyroiditis;
Desmogleins;
Thyroid peroxidase autoantibody
- From:
Chinese Journal of Stomatology
2025;60(2):179-183
- CountryChina
- Language:Chinese
-
Abstract:
Pemphigus vulgaris (PV) is a group of autoimmune bullous diseases characterized by life-threatening intradermal blisters. Hashimoto thyroiditis (HT) is a kind of autoimmune disease with abnormal increase of thyroid peroxidase autoantibody (TPOAb), which is the thyroid specific antibody, leading to hypothyroidism. In recent years, the probability of HT in patients with PV is increasing, and the co-disease may be related to the effect of TPOAb autoantibody on oral keratinocytes. This article reviews the epidemiological relationship between PV and HT and the mechanism of TPOAb in their co-disease, in order to provide ideas for the diagnosis and treatment of both.
