Autophagy in hair physiology and pathology
- VernacularTitle:自噬在毛发生理病理中的研究进展
- Author:
Jiayi SUN
1
;
Xiuzu SONG
1
Author Information
- Publication Type:Journal Article
- Keywords: Autophagy; Hair follicle; Alopecia; Alopecia areata; Androgenetic alopecia
- From: Chinese Journal of Dermatology 2025;58(7):679-682
- CountryChina
- Language:Chinese
- Abstract: Autophagy is the essential mechanism for cell adaptation and survival. Under normal physiological conditions, autophagy activates hair follicle stem cells, induces the transition of hair follicles from the telogen phase to the anagen phase, and maintains the hair growth cycle. Moreover, autophagy can protect dermal papilla cells from damage under pathological conditions. Intervention in autophagy can slow the progress of hair loss due to the existence of impaired autophagy in androgenetic alopecia and alopecia areata. The review summarizes the role of autophagy in hair cycle regulation, cell homeostasis maintenance, and hair regeneration, providing new insights into therapeutic options targeting follicular autophagy signaling pathways.
