Impact of the interaction between nonalcoholic fatty liver disease and overweight/obesity on the risk of mild cognitive impairment in the elderly
10.3760/cma.j.cn115624-20240909-00726
- VernacularTitle:老年人非酒精性脂肪肝病和超重/肥胖的交互作用对轻度认知障碍患病风险的影响
- Author:
Wanying CAI
1
;
Lang XU
;
Yiqing LI
;
Chunli LI
;
Jing HUANG
;
Xiu QU
Author Information
1. 武汉科技大学医学院护理系，湖北省阿尔茨海默病临床研究中心，武汉科技大学脑科学先进技术研究院，武汉 430065
- Publication Type:Journal Article
- Keywords:
Elderly;
Non-alcoholic fatty liver disease;
Overweight/obesity;
Mild cognitive impairment;
Interactions
- From:
Chinese Journal of Health Management
2025;19(8):611-616
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the interaction between non-alcoholic fatty liver disease (NAFLD) and overweight/obesity on the risk of mild cognitive impairment (MCI) in elderly individuals.Methods:This cross-sectional study was based on the Hubei Memory and Aging Cohort Study (HMACS). Cluster random sampling was used to select 5 661 elderly individuals aged≥65 years in Wuhan from 2018 to 2023. Standardized neuropsychological assessments and clinical examinations results were collected. The NAFLD was diagnosed by abdominal ultrasound. The logistic regression analysis was used to analyze the association of NAFLD and overweight/obesity with MCI. The impacts of interaction between NAFLD and overweight/obesity on the risk of MCI were analyzed using both multiplicative and additive models.Results:Among the 5 661 elderly individuals included in the analysis, 2 563 were male and 3 098 were female, with a mean age of (72.24±5.51) years. A total of 2 239 participants (39.6%) resided in rural areas, 2 841 (50.2%) were overweight/obesity, 2 390 (42.2%) had NAFLD, and 1 694 (29.9%) were diagnosed with MCI. The risk of MCI in elderly individuals with NAFLD and overweight/obesity was 2.975 times ( OR=2.975, 95% CI: 2.489-3.557, P<0.001) of that in non-overweight/obese individuals without NAFLD. There was a multiplicative interaction between NAFLD and overweight/obesity on MCI ( OR=1.508, 95% CI: 1.169-1.944, P=0.002). NAFLD and overweight/obesity had an additive interaction effect on the risk of MCI, and the relative excess risk of interaction, attributable proportion of interaction and the synergy index was 1.099 (95% CI: 0.630-1.593), 0.369 (95% CI: 0.222-0.487), 2.256 (95% CI: 1.457-3.492), respectively. Conclusion:There is an interaction between NAFLD and overweight/obesity in elderly individuals, and the co-existence of NAFLD and overweight/obesity increases the risk of MCI in this population.
