Correlation between vitamin D levels and thyroid hormone sensitivity in euthyroid individuals
10.3760/cma.j.cn115624-20250224-00167
- VernacularTitle:甲状腺功能正常人群维生素D水平与甲状腺激素敏感性的相关性
- Author:
Wanting HE
1
;
Pengfei LIU
;
Yuan MA
;
Yuanmeng LI
;
Zihan CHEN
;
Yunyun FEI
;
Naishi LI
Author Information
1. 中国医学科学院 北京协和医学院北京协和医院内分泌科 国家卫生健康委员会内分泌重点实验室，北京 100730
- Publication Type:Journal Article
- Keywords:
Vitamin D;
Thyroid hormone;
Sensitivity;
Physical examination;
Euthyroid
- From:
Chinese Journal of Health Management
2025;19(5):362-367
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between vitamin D levels and thyroid hormone sensitivity in euthyroid individuals.Methods:This cross-sectional study included 5 894 euthyroid individuals who underwent health examinations at the Department of Health Management, Peking Union Medical College Hospital, from December 2023 to February 2024. Thyroid feedback quantile-based index (TFQI), TSH index (TSHI), thyrotroph thyroxine resistance index (TT4RI), and the ratio of free triiodothyronine (FT3)/free thyroxine (FT4) were calculated to assess thyroid hormone sensitivity. Participants were categorized into vitamin D deficiency and non-deficiency groups based on serum 25(OH)D levels. The differences in thyroid hormone sensitivity indices and other clinical characteristics between the two groups were compared. Multivariate logistic regression models were used to analyze the association between vitamin D levels and thyroid hormone sensitivity, and stratified analysis was conducted to explore the association in different genders.Results:Among the study participants, 4 731 (80.3%) had vitamin D deficiency. Compared with the non-deficient group, the deficient group had a lower TFQI (-0.03(-0.31, 0.23) and -0.01(-0.28, 0.27)) ( Z=-2.130, P=0.033) and a higher FT3/FT4 ratio ((0.36±0.04) and (0.35±0.04)) ( t=-4.592, P<0.001). After adjusting for confounding factors including gender and age, the risk of impaired central and peripheral thyroid hormone sensitivity significantly increased in the non-deficient group (TFQI ( OR=1.16, 95% CI: 1.01-1.34); FT3/FT4 ( OR=1.23, 95% CI: 1.05-1.45)) (all, P<0.05). Conclusion:In euthyroid individuals, people with higher vitamin D levels have a higher risk of impaired thyroid hormone sensitivity.
