A case of occupational allergic contact dermatitis caused by sinomenine hydrochloride
10.3760/cma.j.cn121094-20240329-00129
- VernacularTitle:盐酸青藤碱所致职业性变应性接触性皮炎1例
- Author:
Minxia LU
1
;
Qiang FU
1
;
Lifeng TAN
1
;
Liangjian LING
1
Author Information
1. 常州市疾病预防控制中心门诊部，常州 213022
- Publication Type:Journal Article
- Keywords:
Sinomenine;
Allergic contact dermatitis;
Allergic reaction
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2025;43(8):629-631
- CountryChina
- Language:Chinese
-
Abstract:
Sinomenine hydrochloride is an alkaloid preparation commonly used in clinical practice in traditional Chinese medicine, and allergic reactions induced by occupational exposure to it are relatively rare in clinical settings. This article analyzes a case of allergic contact dermatitis in a medical worker after occupational exposure to sinomenine hydrochloride. The patient developed generalized skin rashes with the fingertips as the initial site three months after exposure to sinomenine hydrochloride. The treatment effect was poor without cessation of exposure, while symptoms significantly improved after cessation. The condition persisted, exhibiting a contact-reaction pattern of recurrence upon re-exposure. The serum total IgE level met the criteria for extremely severe allergy. No similar symptoms were observed among colleagues in the same position. After differential diagnosis, the possibility of dermatomyositis was ruled out, and the patient was diagnosed with occupational allergic contact dermatitis.
