A meta-analysis of the association between estimated glomerular filtration rate and the onset and progression of type 2 diabetic retinopathy
10.3760/cma.j.cn115624-20240516-00410
- VernacularTitle:估算肾小球滤过率水平与2型糖尿病视网膜病变发生及进展相关性的荟萃分析
- Author:
Peiyuan HE
1
;
Yuping LIU
1
;
Yumei YANG
1
;
Mo ZHANG
1
;
Ping SHUAI
1
Author Information
1. 四川省医学科学院·四川省人民医院（电子科技大学附属医院）健康管理中心（健康管理研究所），成都 610072
- Publication Type:Journal Article
- Keywords:
Glomerular filtration rate;
Diabetic retinopathy;
Meta-analysis;
Systematic review;
Observational study
- From:
Chinese Journal of Health Management
2025;19(3):213-219
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between estimated glomerular filtration rate (eGFR) and the onset and progression of type 2 diabetic retinopathy (DR).Methods:Observational studies on the relationship between eGFR and the progression of DR were searched in the databases of PubMed, Web of Science, Foreign Medical Literature Retrieval Service (FMRS), China National Knowledge Infrastructure and Wanfang data. The search period was from the inception of the databases to January 20, 2024. Meta-analysis of the association between eGFR and the onset and progression of DR with the research data was conducted by using Review Manager 5.3 and Stata 15.0, the weighted mean difference (WMD) and 95% confidence interval (CI) were calculated. Sensitivity analysis and Egger′s test were performed to assess the result stability and publication bias.Results:A total of 30 studies involving 119 142 patients with type 2 diabetes were included in the analysis. The eGFR in the DR group was significantly lower than that in the non-DR group (WMD=8.11, 95% CI: 5.97-10.25, P<0.001). Subgroup analysis by DR type revealed that patients with diabetic macular edema (WMD=7.61, 95% CI: 3.82-11.40) and proliferative DR (WMD=17.40, 95% CI: 10.13-24.66) had significantly lower eGFR when compared to that in non-DR group (both P<0.001). The subgroup analysis results according to different DR diagnostic criteria showed that both the 2003 International DR Grading Standard Group (WMD=8.55, 95% CI: 5.29-11.81) and the 2002 International Clinical DR Severity Grading Standard Group (WMD=10.70, 95% CI: 7.99-13.41) indicated the statistically significant differences in eGFR in relation to the occurrence and progression of DR. Conclusion:The decrease of eGFR is closely related to the occurrence and progression of DR.
