Effects of different low-dose CT scanning protocols on the screening and evaluation of pulmonary ground-glass nodules in healthy physical examination subjects
10.3760/cma.j.cn115624-20241113-00914
- VernacularTitle:不同低剂量CT扫描方案对健康体检人群肺磨玻璃结节筛查及评估的影响
- Author:
Ernuo WANG
1
;
Wufei CHEN
1
;
Ming LI
1
Author Information
1. 华东医院CT室，上海 200000
- Publication Type:Journal Article
- Keywords:
Tomography Scanners, X-Ray Computed;
Radiation dosage;
Lung;
Ground-glass nodule;
Multislice spiral CT;
Low-dose;
Physical examination
- From:
Chinese Journal of Health Management
2025;19(3):207-212
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects of different low-dose CT scanning protocols on the screening and evaluation of pulmonary ground-glass nodules in healthy physical examination subjects.Methods:The study was a prospective cohort study. A total of 805 healthy subjects who underwent pulmonary CT examinations at Huadong Hospital from March 2016 to December 2021 were included. The first examination was performed using the American GE Discovery CT750 (HDCT), with a tube current of 50 mA (voltage 120 kV), and 41 subjects with pulmonary ground-glass nodules were identified. A follow-up examination was conducted three months later with a tube current of 25 mA, while all other parameters remained consistent. The CT volume dose index (CTDIvol) and effective dose (ED) were recorded for each scan. Two radiologists statistically analyzed the pulmonary ground-glass nodules observed in each scan. The Wilcoxon signed-rank test was used to compare the differences in the detection of ground-glass nodules, diagnostic image acceptance rate, and subjective image quality scores between the two different tube current (I) values.Results:When I was 50 mA, the average CTDIvol and ED were (3.71±0.35) mGy and (1.94±0.24) mSv; When I was 25 mA, the average CTDIvol and ED were (1.84±0.20) mGy and (0.97±0.11) mSv (both P<0.05). Compared with the 50 mA, there was 50% intrinsic dose reduction when I was 25 mA. All the ground-glass nodules detected under the 50 mA circumstance were also detected when I was 25 mA. The diagnostic acceptability and image noise score with I of 25 mA were (4.77±0.42), (4.62±0.49), (4.81±0.39) and (4.63±0.48), (4.17±0.62), (4.84±0.37) and these were (4.82±0.39), (4.78±0.42), (4.84±0.37) and (4.70±0.46), (4.55±0.59), (4.88±0.33) (all P>0.05) with I of 50 mA. The Kappa values for the detection of pulmonary ground-glass nodules, diagnostic image acceptance rate, and subjective noise assessment by the two radiologists were 1.000, 0.706, and 0.885, respectively (all P<0.05). Conclusion:Different low-dose CT scanning protocols can meet the screening and diagnostic requirements for pulmonary ground-glass nodules in the healthy physical examination subjects, but the CT scanning protocol with tube current of 25 mA has a lower radiation dose.
