Association between metabolic score of visceral fat and risk of new-onset stroke in Chinese middle-aged and elderly people: a prospective study based on the CHARLS cohort
10.3760/cma.j.issn.0254-9026.2025.12.019
- VernacularTitle:中老年人内脏脂肪代谢评分与新发脑卒中风险的关联研究
- Author:
Qiang SHI
1
;
Yingying ZHENG
;
Suhang SHANG
;
Qingqing WU
Author Information
1. 延安大学附属医院神经内科，延安 716000
- Publication Type:Journal Article
- Keywords:
Metabolic score of visceral fat;
Stroke;
Residual cholesterol;
Mediation analysis.
- From:
Chinese Journal of Geriatrics
2025;44(12):1750-1756
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between Metabolic Score of Visceral Fat(METS-VF)and new-onset stroke in Chinese middle-aged and elderly individuals aged ≥45 years.Methods:This study is a prospective cohort study that included 3 311 participants from the China Health and Retirement Longitudinal Study(CHARLS)database, with new-onset stroke as the primary endpoint.The association between METS-VF and new-onset stroke was evaluated by Cox proportional hazards model, subgroup analysis and restricted cubic spline(RCS)analysis.Additionally, mediation analysis was used to assess the mediating effect of remnant cholesterol(RC)on the association between METS-VF and stroke.Results:During the 9-year follow-up period, 138(4.2%)middle-aged and elderly individuals experienced stroke.Compared with the lowest quartile group of METS-VF, the fully adjusted HR and 95% CI of new-onset stroke in the second, third and fourth quartiles were 1.78(1.03-3.08), 1.96(1.12-3.44)and 2.19(1.17-4.10), respectively with a statistically significant trend( P for trend<0.05). Mediation analysis indicated that the indirect effect mediated by RC accounted for 13.51% of the association between METS-VF and new-onset stroke( P=0.03), and RCS analysis revealed a linear dose-response relationship between METS-VF and stroke( P for overall=0.022, P for non-linearity=0.198); The results of the subgroup analyses were consistent with the main analyses( P interaction>0.05). Conclusions:METS-VF may serve as a potential biomarker in risk stratification of stroke, with RC partially mediating this association.
