Research progress on the impact of imbalanced intestinal flora on the heavy metal-induced neurotoxicity and probiotics intervention
10.3760/cma.j.cn121094-20240817-00383
- VernacularTitle:肠道菌群失衡在重金属神经毒性中的作用及益生菌干预的研究进展
- Author:
Yunting LI
1
;
Lifan LI
1
;
Xiaojing MENG
1
Author Information
1. 南方医科大学公共卫生学院职业卫生与职业医学系，广东省热带病研究重点实验室，广州 510080
- Publication Type:Journal Article
- Keywords:
Heavy metal poisoning;
Neurotoxicity;
Intestinal flora;
Probiotics
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2025;43(10):795-800
- CountryChina
- Language:Chinese
-
Abstract:
Heavy metals are common occupational hazards that can enter the human body through ingestion, skin contact, and inhalation, damaging various systems including the nervous system and causing a serious disease burden. Numerous studies have shown that heavy metal-induced neurotoxicity is closely linked to intestinal flora imbalance, with exposure to heavy metals leading to a reduction in the diversity of intestinal flora and a decrease in beneficial intestinal bacteria. Due to their few adverse reactions and significant health-regulating effects, probiotics and their formulations are widely used. Supplementing probiotics can alleviate heavy metal-induced neurotoxicity by modulating intestinal flora and their metabolites, reducing inflammation and oxidative stress, and adsorbing heavy metal ions to facilitate their excretion. This article takes four common heavy metals, namely lead, mercury, cadmium and manganese, as examples to review the role of intestinal flora imbalance in the neurotoxicity of heavy metals and the mechanism and application of probiotic intervention treatment, aiming to provide new ideas for the prevention and treatment of heavy metal neurotoxicity and explore the potential mechanism and application value of probiotic intervention.
