The role and mechanism of high-mobility group box 1 (HMGB1) in the pathogenesis of silica associated chronic obstructive pulmonary disease
10.3760/cma.j.cn121094-20240412-00164
- VernacularTitle:高迁移率族蛋白B1在矽尘相关慢性阻塞性肺疾病发病中的作用与机制
- Author:
Ziyang XU
1
;
Jin HE
Author Information
1. 山东第一医科大学（山东省医学科学院）公共卫生专业，济南 250062
- Publication Type:Journal Article
- Keywords:
Pneumoconiosis;
Diagnosis;
Chronic obstructive pulmonary disease, COPD;
Silica dust;
Mechanisms of pathogenesis
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2025;43(10):781-785
- CountryChina
- Language:Chinese
-
Abstract:
Silica dust is known as the most important risk factor of chronic obstructive pulmonary disease (COPD), and COPD is a leading cause of the third mortality worldwide. Workers exposed to silica dust are at increased risk of COPD as a result of being exposed to silica particles for extended periods of time. While clear links have been established between silica exposure and the development of COPD, the mechanisms are still poorly understood. However, both cigarette and silica combination exposure can be easy to result in COPD. Here we review the current understanding of silica-induced COPD, including incubation period, and the use of experimental animal models for better understanding these mechanisms of pathogenesis. The review summarizes important new knowledge and presents new research directions that are likely to provide new insights, diagnosis and treatments of silica-induced COPD.
