Study on the influencing factors and interaction effects of mild cognitive impairment in elderly people in high fluoride areas
10.3760/cma.j.issn.0254-9026.2025.11.015
- VernacularTitle:高氟地区老年人轻度认知功能障碍影响因素及其交互作用研究
- Author:
Fang LI
1
;
Yang WANG
1
;
Yushan CUI
1
;
Yani DUAN
1
;
Wenfeng LI
1
;
Dandan ZHANG
1
Author Information
1. 天津市疾病预防控制中心环境健康与公共卫生所，天津 300011
- Publication Type:Journal Article
- Keywords:
High fluoride exposure;
Mild cognitive impairment;
Elderly;
Risk factors;
Interaction
- From:
Chinese Journal of Geriatrics
2025;44(11):1570-1577
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the main influencing factors of mild cognitive impairment(MCI)in the elderly and explore the interaction between high fluoride exposure and related co-factors on MCI.Methods:A cross-sectional study was conducted from May to December 2024 in four towns in the rural areas of Tianjin(two historically high-fluoride towns and two non-high-fluoride towns). A total of 125 elderly people aged 60 years and above were randomly selected from each township.MCI was diagnosed using the Mini-Mental State Examination(MMSE)and Montreal Cognitive Assessment-Basic(MoCA-B)according to the diagnostic criteria for MCI.Binary logistic regression was used to analyze the influencing factors of MCI, and conditional logistic regression was employed to assess multiplicative and additive interaction effects.Results:A total of 481 participants were included, with 354 in the normal group and 127 in the MCI group, and the incidence of MCI was 26.40%.Univariate analysis showed that MCI was associated with age, annual household income per capita, high fluoride exposure, life stress, depression, and abnormal urinalysis( χ2=4.241, 4.017, 4.552, 7.143, 4.151, 5.113, all P<0.05). Multivariate logistic regression revealed that after adjusting for other confounders, high fluoride exposure( OR=1.816, 95% CI: 1.177-2.802), age ≥70 years( OR=1.584, 95% CI: 1.034-2.428), depression( OR=2.106, 95% CI: 1.042-4.254), and abnormal urinalysis( OR=1.595, 95% CI: 1.041-2.444)increased the risk of MCI.Compared with severe life stress, moderate stress( OR=0.254, 95% CI: 0.082-0.790)reduced the risk of MCI.No multiplicative or additive interaction was found between high fluoride exposure and depression, life stress, or abnormal urinalysis. Conclusions:High fluoride exposure, age ≥70 years, depression, abnormal urinalysis, and severe life stress may increase the risk of MCI in the elderly, but there is no interaction among them.
