Death-associated protein kinase 1 in ischemic stroke: mechanisms and progress in targeted drug development
10.3760/cma.j.issn.0254-9026.2025.10.020
- VernacularTitle:死亡相关蛋白激酶1在缺血性脑卒中中的作用机制及靶向药物开发进展
- Author:
Guangming YANG
1
;
Jiahui WANG
;
Qian LIU
;
Erqing CHAI
Author Information
1. 甘肃中医药大学第一临床医学院，兰州 730000
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain ischemia;
Apoptosis;
Cell death
- From:
Chinese Journal of Geriatrics
2025;44(10):1443-1449
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke is more common in the elderly, characterized by rapid onset, high incidence, high disability rate, and high mortality rate.It often causes severe cellular dysfunction and brain damage, imposing a significant burden on families and society.Death-associated protein kinase 1(DAPK1)is a calcium/calmodulin(Ca 2+ /CaM)-dependent serine/threonine(Ser/Thr)protein kinase that plays a crucial role in regulating brain damage caused by ischemic stroke.Studies have shown that DAPK1 activity is regulated by phosphorylation and mediates the pathophysiological processes of ischemic stroke through multiple signaling pathways, including DAPK1-N-methyl-D-aspartate(DAPK1-NMDA), DAPK1-NMDA), DAPK1-tumor suppressor protein p53(DAPK1-p53), DAPK1-microtubule-associated protein Tau(DAPK1-Tau), and DAPK1-dangerous signaling(DAPK1-DANGER), among others.Blocking these signaling pathways can significantly improve neuronal damage following ischemic stroke.This article reviews the related signaling pathways, mechanisms of action, and progress in targeted drug development of DAPK1 in ischemic stroke, aiming to provide references for future research and treatment of ischemic stroke.
