Advances in biomarkers for delayed encephalopathy after acute carbon monoxide poisoning

VernacularTitle:急性一氧化碳中毒迟发性脑病生物标志物研究进展
Author: Guoli HE ¹ ; Pei SHEN ; Manhong ZHOU
Author Information

1. 遵义医科大学附属医院急诊科，遵义　563000
Publication Type:Journal Article
Keywords: Carbon monoxide poisoning; Delayed encephalopathy after acute carbon monoxide poisoning; Biomarkers; Therapeutic targets; Prediction
From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2025;43(6):472-477
CountryChina
Language:Chinese
Abstract: Acute carbon monoxide poisoning (ACMP) is a common harmful gas poisoning. Underwent systematic treatment and a 2-3 week pseudo-healing period, some ACMP patients may still develop delayed encephalopathy after acute carbon monoxide poisoning (DEACMP). DEACMP is the most severe complication that could happen to ACMP patients and comes with an exceeding high disability rate. Early identification and adequate intervention measures of DEACMP are particularly crucial for preventing its occurrence in clinical practice. At present, multiple studies have found that after ACMP occurred, a series of biomarkers showed predictive value for detecting the occurrence and development of DEACMP. This paper reviews these biomarkers and their predictive effects on DEACMP, aiming to provide theoretical guidance for the prevention and intervention of DEACMP.