Research progress of natural killer cell in anti-senescence

VernacularTitle:自然杀伤细胞在抗衰老中的研究进展
Author: Xian DUAN ¹ ; Qian HE ¹ ; Hao NIE ¹ ; Lihui LIANG ¹ ; Qing ZHENG ¹
Author Information

1. 湖南省人民医院老年科，长沙　410000
Publication Type:Journal Article
Keywords: Senescence; Natural killer cell; Senescence-associated Secretory Phenotype
From: Chinese Journal of Geriatrics 2025;44(9):1298-1303
CountryChina
Language:Chinese
Abstract: Nature killer(NK)cells are lymphocytes of the innate immune that play a significant role in aging through direct cell killing and secretion of cytokines.NK cells can delay the occurrence of age-related diseases and prolong lifespan by eliminating senescencent cells.Significant progress has been achieved in the research utilizing NK cells to improve aging.This review aims to summarize that the recent research on the mechanism of NK cells in the context of senescence, as well as the progress made in anti-senescence interventions through animal and clinical studies.Nevertheless, substantial challenges remain for the clinical application of NK cell-based anti-senescence therapies.