Advances in the emphysema phenotype of chronic obstructive pulmonary disease
10.3760/cma.j.cn114798-20250711-00863
- VernacularTitle:肺气肿表型慢性阻塞性肺疾病的研究进展
- Author:
Xiaoxue WU
1
;
Xiansheng LIU
;
Ruiying WANG
Author Information
1. 山西医科大学第三医院（山西白求恩医院 山西医学科学院 同济山西医院）呼吸与危重症医学科，太原 030032
- Publication Type:Journal Article
- Keywords:
Pulmonary disease, chronic obstructive;
Emphysema;
Disease management
- From:
Chinese Journal of General Practitioners
2025;24(12):1569-1575
- CountryChina
- Language:Chinese
-
Abstract:
Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition with diverse phenotypes and endotypes. The emphysema phenotype, characterized by destruction of the terminal bronchioles and alveolar walls, is associated with more severe lung function impairment, heightened airway inflammation, and greater systemic dysfunction compared to other subtypes. Early diagnosis via biomarkers, signaling pathway analysis, and imaging, combined with targeted therapies, may improve patient outcomes. However, further research is needed to fully elucidate this phenotype. This review summarizes recent advances in the pathology, biomarkers, signaling pathways, and clinical management of the emphysema phenotype of COPD, aiming to enhance its recognition and inform future research.
