Interstitial pneumonia caused by intravesical BCG instillation:case report and literature review
10.3760/cma.j.cn114798-20250206-00079
- VernacularTitle:卡介苗膀胱内灌注致相关间质性肺炎1例并文献复习
- Author:
Zhangyan CHEN
1
;
Yao LIU
;
Haiyan LEI
;
Mengnan HAO
;
Congying LU
Author Information
1. 复旦大学附属中山医院厦门医院全科医学科，厦门361015
- Publication Type:Journal Article
- Keywords:
BCG vaccine;
Pneumonia;
Administration, intravesical
- From:
Chinese Journal of General Practitioners
2025;24(9):1148-1152
- CountryChina
- Language:Chinese
-
Abstract:
A bladder cancer patient underwent intravesical Bacillus Calmette-Guérin (BCG) instillation in Xiamen Branch, Zhongshan Hospital, Fudan University in April 2023. Following 8 instillations the patient presented with fever, cough and dyspnea, and was diagnosed as interstitial pneumonia (IP). Symptoms resolved after anti-tuberculosis and methylprednisolone treatment, with subsequent successful discharge. Using the keywords ′Bacillus Calmette-Guérin, ′ ′intravesical instillation, ′ ′pneumonia, ′ Wanfang Data, China National Knowledge Infrastructure(CNKI), Weipu(VIP), and PubMed databases were searched for relevant literature published between January 2014 and June 2024, and 20 cases of BCG instillation-induced pneumonia were retrieved, including 10 IP cases and 10 miliary pneumonia cases. Among 10 IP cases, 7 received corticosteroids combined with anti-tuberculosis therapy. Two cases unresponsive to combination therapy resulted in mortality, while others showed therapeutic efficacy. Miliary pneumonia demonstrated better prognosis, with 6 cases achieving complete remission through anti-tuberculosis monotherapy. The results indicate that severe BCG-related pneumonia generally necessitates combined anti-tuberculosis and corticosteroid therapy.
