Clinical analysis of 11 cases of pediatric protein-losing gastroenteropathy manifested as chronic diarrhea
10.3760/cma.j.cn114798-20250425-00364
- VernacularTitle:以慢性腹泻为表现的儿童蛋白丢失性胃肠病11例临床分析
- Author:
Jianyun HAO
1
;
Xuemei ZHONG
1
;
Youzhe GONG
1
;
Huijuan NING
1
;
Yanfei CHEN
1
Author Information
1. 首都医科大学附属首都儿童医学中心消化内科，北京 100020
- Publication Type:Journal Article
- Keywords:
Protein-losing enteropathy;
Child;
Lymphangiectasis, intestinal;
Hypoalbuminemia;
Nutritional support
- From:
Chinese Journal of General Practitioners
2025;24(9):1143-1147
- CountryChina
- Language:Chinese
-
Abstract:
A retrospective analysis was conducted on the clinical data of 11 children with Protein-Losing Gastrointestinal Disease (PLG) presented with chronic diarrhea who were admitted to the Capital Institute of Pediatrics Affiliated to Capital Medical University from 2018 to 2025. The data included etiology, laboratory test results, endoscopic and imaging findings, treatment regimens, and prognosis. Among them, there were 6 males and 5 females, with a median age of 7.8 (1.6, 12.0) months, and 9 cases ≤1 year. The etiologies were intestinal lymphangiectasia ( n=5), infection-related enteritis ( n=2), Crohn′s disease ( n=1), eosinophilic gastroenteritis ( n=1), and unknown ( n=2). Clinical manifestations were characterized by chronic diarrhea ( n=11), hypoalbuminemia ( n=11), and immune dysfunction ( n=8). Gastrointestinal endoscopy was performed in 9 cases, and diagnosis was confirmed by endoscopic pathology in 8 cases. Among the 5 cases of intestinal lymphangiectasia, only 3 were confirmed by 99Tc-labeled human serum albumin ( 99Tc m-HSA) radionuclide imaging. Five cases of lymphangiectasia were treated with a high medium-chain triglyceride diet, 2 infectious cases were treated with antibacterial agens, and 3 immune diseases received immunomodulators. Ten cases were cured and discharged, while 1 child died of sepsis after intestinal malrotation surgery. It is suggested that childhood PLG mostly occurs in infancy, with intestinal lymphangiectasia as the main etiology. Endoscopic pathology is the main diagnostic method, and with the combination of nutritional and immunomodulatory therapy, the prognosis is good for most of PLG patients.
