Relationship between four unconventional lipid indicators and mild cognitive impairment in middle-aged and elderly patients with type 2 diabetes mellitus
10.3760/cma.j.cn114798-20250406-00280
- VernacularTitle:四种非传统脂质参数与中老年2型糖尿病患者轻度认知障碍的关系研究
- Author:
Qi ZHAO
1
;
Li MA
;
Pinghui ZHU
;
Taihong LYU
;
Yuru CHEN
Author Information
1. 首都医科大学附属北京天坛医院全科医疗科，北京 100070
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, type 2;
Mild cognitive impairment;
Lipid derivatives;
Residual cholesterol;
Atherogenic index;
Triglyceride to high-density lipoprotein
- From:
Chinese Journal of General Practitioners
2025;24(6):686-692
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship of plasma residual cholesterol (RC), atherogenic index (AI), triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio (THR) and low-density lipoprotein cholesterol (LDL-C) to HDL-C ratio (LHR) with mild cognitive impairment(MCI) in middle-aged and elderly patients with type 2 diabetes mellitus (T2DM).Methods:This was a cross-sectional study. A total of 318 T2DM patients aged 50-80 years admitted to the general practice ward of Tiantan Hospital from October 2023 to May 2024 were enrolled. The relevant clinical data were collected, including patient basic information, glycated hemoglobin, lipid test results, and cognitive level was evaluated using the Mini-Mental State Examination (MMSE) form. According to MMSE scores, the patients were divided into the MCI group ( n=102) and the normal cognitive (NC) group ( n=216). Results:Compared with the NC group, patients in MCI group had a older age, longer diabetes duration, lower education level, higher HbA1c, and higher plasma TG levels ( P<0.05). The levels of RC, AI, LHR, and THR in the MCI group were significantly higher than those in the NC group ( P<0.001). Multivariate logistic regression analysis showed that RC ( OR=1.981, P=0.045), AI ( OR=1.657, P=0.043), LHR ( OR=4.360, P=0.001), and THR ( OR=2.908, P=0.002) were independently associated with mild cognitive impairment in T2DM patients. Age-stratified analysis revealed that among T2DM patients aged 60 to 69 years, all four plasma lipid parameters were associated with the risk of MCI in T2DM patients ( P<0.05). Conclusion:Plasma levels of RC, AI, LHR and THR are significantly associated with MCI in middle-aged and elderly T2DM patients, while LHR and THR have a closer association with MCI.
