Correlation analysis of urinary sodium excretion and early renal functional impairment in patients with primary hypertension
10.3760/cma.j.cn114798-20250220-00125
- VernacularTitle:原发性高血压患者尿钠排泄量与早期肾功能损伤的相关性分析
- Author:
Jiaqi BAI
1
;
Nana YIN
;
Lijun LI
;
Chi WANG
;
Xiangyu WANG
;
Siyu YAO
;
Kaiwei ZHANG
;
Qian XIN
;
Hao XUE
Author Information
1. 解放军总医院第六医学中心心血管内科，北京 100048
- Publication Type:Journal Article
- Keywords:
Hypertension;
Renal function;
Urinary sodium;
Urinary microalbumin
- From:
Chinese Journal of General Practitioners
2025;24(6):679-685
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation between 24-hour urinary sodium excretion and early renal function impairment in patients with primary hypertension.Methods:This cross-sectional study included patients with primary hypertension who were admitted to the Department of Cardiology of the Chinese People′s Liberation Army General Hospital between January 2021 and October 2024. Patients were divided into low-sodium, medium-sodium, and high-sodium groups based on their 24-hour urinary sodium excretion. General clinical data were collected using the electronic medical record system. Urinary sodium, protein, and microalbumin excretion were analyzed from 24-hour urine samples. Spearman correlation analysis was used to explore the relationship between 24-hour urinary sodium excretion and urinary microalbumin excretion. A multiple linear regression model was used to further assess the independent association between these variables. Subgroup analyses were conducted based on age were performed to determine whether age influenced the relationship between urinary sodium excretion and renal function impairment.Results:A total of 1 065 patients with primary hypertension were included, with a mean age of (55.26±14.06) years, including 568(53.33%) males. The low-sodium, medium-sodium, and high-sodium groups included 223, 579, and 263 patients, respectively. The 24-hour urinary microalbumin excretion in the high-sodium group was significantly higher than in the medium-sodium and low-sodium groups, and this trend remained consistent across different age groups (all P<0.05). Spearman correlation analysis showed a positive correlation between 24-hour urinary sodium excretion and urinary microalbumin excretion ( r=0.220, P<0.001), and this relationship was observed in all age groups (all P<0.05). Multiple linear regression analysis confirmed an independent association between 24-hour urinary sodium excretion and urinary microalbumin excretion (all P<0.001), which persisted across different age groups (all P<0.05). Conclusion:In patients with primary hypertension, 24-hour urinary sodium excretion is closely associated with microalbumin excretion, suggesting a potential link to early renal function impairment.
