Clinical features of dystonia in patients with different types of atypical Parkinson syndrome
- VernacularTitle:不同类型非典型帕金森综合征患者肌张力障碍的临床特征分析
- Author:
Dongdong WU
1
;
Jing HE
1
;
Yunfei LONG
1
;
Huijing LIU
1
;
Wei DU
1
;
Huimin CHEN
1
;
Shuhua LI
1
;
Ying JIN
1
;
Xinxin MA
1
;
Wen SU
1
;
Haibo CHEN
1
Author Information
- Publication Type:Journal Article
- Keywords: Multiple system atrophy; Progressive supranuclear palsy; Corticobasal degeneration; Dystonia
- From: Chinese Journal of General Practitioners 2025;24(4):465-470
- CountryChina
- Language:Chinese
- Abstract: Objective:To evaluate the clinical features of dystonia in patients with different types of atypical Parkinson syndrome (APS).Methods:A total of 104 patients with APS admitted in the Department of Neurology, Beijing Hospital from January 2015 to June 2023 were enrolled in the study, including 57 cases of multiple system atrophy (MSA), 38 cases of progressive supranuclear palsy (PSP) and 9 cases of corticobasal degeneration (CBD). Among 104 cases there were 63 males (60.6%), the mean age of patients was (62.3±8.9) years (54 to 73 years). The sex, age at onset, disease duration, first symptom, clinical features of dystonia and other neurological signs, response to levodopa therapy, numbers of Hoehn & Yahr scale≥3 after 3 years of disease, and MRI findings were documented in patients with different type APS.Results:The overall frequency of dystonia in this series was 45.2%(47/104), and 33.3% (19/57) for MSA group, 50.0% (19/38) for PSP group, 9/9 for CBD group. The types of dystonia were anterocollis, retrocollis, blepharospasm, oromandibular, foot/limb dystonia, Pisa syndrome and myoclonus. In all 47 cases presenting dydtonia, dystonia was not the first complaint and it did not respond to levodopa therapy.Conclusion:In this series of atypical Parkinson syndrome, dystonia is a common feature of the disease, while it is not the first symptom at disease onset, and usually does not respond to levodopa therapy.
