Advances in therapeutic drugs for Alzheimer disease
10.3760/cma.j.cn114798-20241016-00819
- VernacularTitle:阿尔茨海默病药物治疗进展
- Author:
Lixiang ZHANG
1
;
Weizhong XIAO
Author Information
1. 北京大学第三医院全科医学科，北京100191
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
Drug treatment;
Amyloid;
Tau proteins
- From:
Chinese Journal of General Practitioners
2025;24(3):336-342
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer disease is a progressive neurodegenerative disorder which has emerged as a major public health concern with the global population aging, and the development of effective therapeutic agents has become increasingly urgent due to its rapid increase in prevalence. There is some progress in drug development, however, the majority of new drugs have failed to demonstrate sustained clinical efficacy in large-scale trials. In addition, high costs, severe side effects have further hindered the widespread application of these therapies. This article reviews recent progress in the development of pharmacological treatments for Alzheimer disease, focusing on disease-modifying therapies targeting amyloid-β and tau proteins, also analyzes the results of phase 2 and phase 3 clinical trials of traditional and novel drugs. Future research efforts should continue to explore novel therapeutic targets and strategies to offer more effective treatment options for patients with Alzheimer disease.
