Clinicopathological features and ATRX application in hepatic angiosarcoma
10.3760/cma.j.issn.0254-9026.2025.03.015
- VernacularTitle:肝脏血管肉瘤的临床病理特征及α地中海贫血伴智力低下综合征X连锁的表达特征
- Author:
Zhouying LIU
1
;
Jun DU
1
;
Jinsong ZHANG
1
;
Longteng LIU
1
;
Dongge LIU
1
;
Chongqing YANG
1
Author Information
1. 北京医院病理科 国家老年医学中心 中国医学科学院老年医学研究院，北京 100730
- Publication Type:Journal Article
- Keywords:
Angiosarcoma;
Liver;
alpha-thalassemia mental retardation X-linked
- From:
Chinese Journal of Geriatrics
2025;44(3):330-334
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinicopathological characteristics and the application of ATRX(alpha-thalassemia mental retardation X-linked)in hepatic angiosarcoma.Methods:We retrospectively analyzed the pathological and clinical data of seven patients diagnosed with hepatic angiosarcoma at the Department of Pathology, Beijing Hospital, between 2014 and 2023.ATRX immunohistochemical staining was conducted.Results:Among the patients, six were identified incidentally during physical examinations, while only one patient presented with abdominal pain.Six patients had multiple nodules, whereas one had a solitary tumor.The morphological features were diverse; high-grade angiosarcoma exhibited liver plate atrophy and hepatic sinusoids lined with atypical cells, while low-differentiated angiosarcoma displayed a higher degree of atypia and should be differentiated from other sarcomas.Tumor cells expressed vascular endothelial markers, including CD31(platelet endothelial cell adhesion molecule-1), CD34(hematopoietic progenitor cell antigen CD34), and ERG(Ets-related gene).Additionally, loss of ATRX expression was observed in four patients.Conclusions:Hepatic angiosarcoma is characterized by a lack of specific clinical manifestations and imaging findings.A comprehensive analysis of clinical symptoms, morphological features, and immunohistochemical staining—particularly for vascular markers and ATRX—is essential for an accurate pathological diagnosis.
