Advances in the study of mitokines in aging and its related diseases
10.3760/cma.j.issn.0254-9026.2025.08.023
- VernacularTitle:线粒体因子在衰老及其相关疾病中的研究进展
- Author:
Guochao LI
1
;
Li QIN
1
;
Liqin WEI
1
;
Juan LIU
1
Author Information
1. 南京医科大学第一附属医院（江苏省人民医院）老年内分泌科，南京 210029
- Publication Type:Journal Article
- Keywords:
Mitochondria;
Aging;
FGF21;
GDF15;
Humanin
- From:
Chinese Journal of Geriatrics
2025;44(8):1162-1169
- CountryChina
- Language:Chinese
-
Abstract:
As a special type of signaling molecules, mitokines have attracted widespread attention in the fields of cell biology and aging research in recent years.Currently researchers discovered mitokines including fibroblast growth factor 21, growth differentiation factor 15 and humanin, etc., which are mainly secreted and produced by stressed cells during mitochondrial stress(e.g., oxidative stress, metabolic stress, and toxin exposure). Through different signaling pathways, mitokines regulate cellular function and metabolic status, playing an important role in maintaining the health of organisms and regulating the aging process.This article summarizes the current research progress on mitokines and the occurrence and development of aging, as well as their roles in aging-related diseases.
