Recent Developments in the Mechanisms and Management Strategies for Sarcopenia
10.3760/cma.j.issn.0254-9026.2025.08.022
- VernacularTitle:肌少症的机制与干预措施研究进展
- Author:
Qiaofeng MA
1
;
Jia SONG
1
;
Li CHEN
1
Author Information
1. 山东大学齐鲁医院内分泌与代谢病科，济南 250012
- Publication Type:Journal Article
- Keywords:
Sarcopenia;
Muscular diseases;
Muscular strength;
Aging
- From:
Chinese Journal of Geriatrics
2025;44(8):1156-1161
- CountryChina
- Language:Chinese
-
Abstract:
Skeletal muscle is the largest organ in the human body and plays a crucial role in motor functions.With aging, skeletal muscle mass and function progressively decline, a phenomenon known as sarcopenia.This condition can result in various adverse health outcomes, including reduced muscle function, weakness, cognitive decline, increased medical expenses, and elevated mortality rates, thereby exerting significant social and lifestyle impacts.Several mechanisms contribute to the development of sarcopenia, including immune system alterations, inflammation, lipid accumulation, mitochondrial dysfunction, nicotinamide adenine dinucleotide metabolic disorders, and impaired muscle stem cell regeneration.Although lifestyle modifications, pharmacological therapies, mitochondrial transplantation, and stem cell therapy have shown promise in addressing sarcopenia, there remains a need for more effective and targeted interventions.This article aims to discuss the pathogenesis of sarcopenia and its interventions, providing new insights for clinical treatment.
