Research progress on microvascular endothelial cell senescence
10.3760/cma.j.issn.0254-9026.2025.08.021
- VernacularTitle:微血管内皮细胞衰老研究进展
- Author:
Weiqi LIU
1
;
Yingyu WANG
;
Mingming LIU
Author Information
1. 中国医学科学院微循环研究所，北京 100005
- Publication Type:Journal Article
- Keywords:
Microvascular aging;
Microvascular endothelial cells;
Aging-related diabetes;
Inflammatory mediators;
Oxidative stress
- From:
Chinese Journal of Geriatrics
2025;44(8):1149-1155
- CountryChina
- Language:Chinese
-
Abstract:
Microvascular aging is a complex physiological process associated with advancing age.The aging and dysfunction of microvascular endothelial cells serve as critical markers of this phenomenon, characterized by increased expression of inflammatory factors, heightened oxidative stress, and structural damage to the microvasculature.This process is closely linked to age-related diseases such as diabetes in the elderly and cardiovascular disorders, significantly impacting the quality of life and overall health of older adults.Biomarkers, including the reactive hyperemia index, circulating endothelial progenitor cells, and extracellular microvesicles, play a vital role in assessing microvascular health and predicting cardiovascular events.Interventions targeting microvascular aging, which encompass lifestyle modifications, pharmacotherapy, and strategies aimed at preserving microvascular structure and endothelial cell function, hold promise for delaying or reversing the process of microvascular aging.
