Research progress of functions and mechanisms of tRNA-derived small RNA in aging-related diseases
- VernacularTitle:tRNA衍生小分子在衰老相关疾病中的作用与机制的研究进展
- Author:
Wenlin LI
1
;
Yao YANG
1
;
Que WANG
1
;
Kun XU
1
;
Mingjing YAN
1
;
Xiuqing HUANG
1
;
Lin DOU
1
;
Weiqing TANG
1
;
Jian LI
1
;
Tao SHEN
1
Author Information
- Publication Type:Journal Article
- Keywords: Aging; Transfer RNA; Neurodegene-rative disease
- From: Chinese Journal of Geriatrics 2025;44(1):92-98
- CountryChina
- Language:Chinese
- Abstract: The primary role of transfer RNA(tRNA)is to connect a specific amino acid to its 3' end, use its anticodon to match the codon on messenger RNA(mRNA), and deliver the corresponding amino acid to the ribosome for protein synthesis.tRNA exists in two forms: precursor tRNA and mature tRNA.When acted upon by enzymes like Dicer, elaC ribonuclease Z 2(ELAC2), angiopoietin(ANG), and other ribonucleases, tRNA is broken down into tRNA-derived stress-induced RNA(tiRNA)and tRNA-derived fragments(tRF).Recent advancements in RNA sequencing technology have led to increased interest in tiRNA and tRF, shedding light on their roles in various physiological and pathological processes.tRNA-derived small molecules(tsRNA)function similarly to microRNA(miRNA), influencing gene expression and protein synthesis.They show promise as diagnostic markers and potential therapeutic targets for age-related diseases.This review offers a comprehensive analysis of tsRNA classification, biological functions, research advancements, and clinical applications in age-related conditions.
