Clinical use of metformin in aging and aging-related diseases
10.3760/cma.j.issn.0254-9026.2025.04.003
- VernacularTitle:二甲双胍在衰老和衰老相关疾病中的临床应用
- Author:
Chenyu NIE
1
;
Xinguo HOU
1
Author Information
1. 山东大学齐鲁医院内分泌与代谢病科，济南 250012
- Publication Type:Journal Article
- Keywords:
Metformin;
Aging;
Diabetes Mellitus;
Molecular Mechanisms of Pharmacological Action
- From:
Chinese Journal of Geriatrics
2025;44(4):415-420
- CountryChina
- Language:Chinese
-
Abstract:
Aging is a natural process experienced by all living organisms, and the increasing elderly population presents a significant public health challenge in the 21st century.Consequently, the quest for new anti-aging drugs that can decelerate the aging process and enhance the health of the elderly has become an urgent priority.Metformin, an oral anti-diabetic medication, is primarily utilized for the treatment of type 2 diabetes mellitus.Its main mechanism of action involves the inhibition of hepatic glucose production and the reduction of insulin resistance.Beyond its anti-diabetic properties, metformin has been strongly associated with aging and age-related diseases.This article provides a concise review of recent advancements in the application of metformin in the context of aging and age-related diseases.
