Research progress on sarcopenia with malignant tumor in the elderly
10.3760/cma.j.issn.0254-9026.2025.03.021
- VernacularTitle:老年恶性肿瘤合并肌少症的研究进展
- Author:
Yanqing SHI
1
;
Hui HAN
;
Huashan HONG
Author Information
1. 福建医科大学附属协和医院老年医学科 福建省血管衰老重点实验室 福建省老年医学研究所 福建省老年血管衰老与脑老化医学研究中心，福州 350001
- Publication Type:Journal Article
- Keywords:
Malignant tumor;
Sarcopenia;
Nutritional therapy;
Progressive resistance exercise
- From:
Chinese Journal of Geriatrics
2025;44(3):366-371
- CountryChina
- Language:Chinese
-
Abstract:
Sarcopenia is highly prevalent in old patients with cancer, forcing a vicious circle.Sarcopenia increases the incidence of tumor treatment-related side effects and even mortality risk in the elderly.The progression and certain treatments of cancer can lead to an increased risk or severity of sarcopenia, which exacerbate in older adults, accompanied by aggravated physical function impairment.Except for patients with terminal malignant tumors undergoing palliative therapy, screening for sarcopenia is recommended for older patients at the time of diagnosis of malignancy and before initiation of tumor-related treatment, and a more comprehensive geriatric assessment should be conducted, if necessary, to improve the detection rate of sarcopenia and identify the risk factors of sarcopenia.A clear treatment plan should be tailored to meet the needs of tumor treatment at each stage, and the benefits and risks should be weighed in consideration of the intervention goals and physical function status.It is a promising intervention that holistic care including individualized nutrition therapy and progressive resistance training, in collaboration with the multi-disciplinary team, to maintain or improve skeletal muscle mass, strength and physical function, and improve the prognosis and outcome of cancer among elderly patients with sarcopenia.
