Analysis of cardiovascular related adverse events in older patients with second-generation H1-antihistamines
10.3760/cma.j.issn.0254-9026.2025.01.011
- VernacularTitle:第二代H1抗组胺药在老年患者中的心血管相关不良事件分析
- Author:
Zhonghui LIU
1
;
Jiayu LI
;
Shuang ZHOU
;
Ying ZHOU
;
Xinmin LIU
Author Information
1. 北京大学第一医院老年病内科，北京 100034
- Publication Type:Journal Article
- Keywords:
Histamine H1 antagonists;
Adverse reaction;
Cardiovascular-related adverse events
- From:
Chinese Journal of Geriatrics
2025;44(1):68-73
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To conduct signal detection and analysis of cardiovascular-related adverse events associated with second-generation H1 antihistamines(sgAH)in the elderly population, utilizing the Food and Drug Administration adverse event reporting system(FAERS)database.The findings provide a reference for assessing the clinical drug safety of sgAH in the elderly.Methods:A cross-sectional study was conducted.Four methods were utilized to detect signals of cardiovascular-related adverse events associated with sgAHs in the FAERS database, covering the period from the first quarter of 2004 to the first quarter of 2024.These methods included the reporting odds ratio, the Medicines and Healthcare Products Regulatory Agency method, the Bayesian Confidence Propagation Neural Network method, and the multi-item gamma Poisson shrinker method.Subgroup analyses were performed on both the overall population and the elderly population(aged ≥65).Results:A total of 1 065 reports of cardiovascular-related adverse events involving sgAHs such as loratadine, desloratadine, cetirizine, levocetirizine, and fexofenadine were collected.In the overall population, palpitations were identified as a positive signal, while desloratadine also demonstrated positive signals for tachycardia and prolonged electrocardiogram QT interval.In the elderly population, both palpitations and prolonged electrocardiogram QT interval were recognized as positive signals, exhibiting higher information component(IC)values and empirical Bayesian geometric mean(EBGM)values compared to the overall population.Furthermore, loratadine and desloratadine were also identified as positive signals for prolonged electrocardiogram QT interval in the elderly.Conclusions:Palpitations have been identified as a significant indicator of cardiovascular-related adverse events associated with sgAHs.Elderly patients should be particularly vigilant regarding the risk of prolonged QT intervals on electrocardiograms.
