Autophagy defects affect pathological changes of Alzheimer's disease
10.3760/cma.j.issn.0254-9026.2025.01.003
- VernacularTitle:自噬缺陷影响阿尔茨海默病的病理改变
- Author:
Min LI
1
;
Junyu HUANG
1
;
Zhen WEI
1
Author Information
1. 湖北省阿尔茨海默病临床医学研究中心 脑科学先进技术研究院 武汉科技大学医学部，武汉 430065
- Publication Type:Journal Article
- Keywords:
Autophagy defects;
Alzheimer's disease;
Aβ protein deposition;
Tau protein aggregation;
Targeted therapy
- From:
Chinese Journal of Geriatrics
2025;44(1):16-20
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD), the most prevalent form of dementia among the elderly, is a progressive neurodegenerative disorder characterized by an insidious onset.Although the precise pathogenesis of AD has not been fully elucidated, recent studies have identified autophagy defects as a pivotal factor in the progression of the disease.These autophagy defects lead to the deposition of Aβ protein, aggregation of tau protein, neuronal loss, synaptic damage, neuroinflammation, and mitochondrial dysfunction, all of which may contribute to the development of AD and influence its occurrence and progression.This review aims to examine the mechanisms underlying defective autophagy, highlight its impact on the pathological changes associated with AD, and discuss potential therapeutic strategies to address autophagy deficiencies, thereby providing new insights for the prevention and treatment of AD.
