Association between menstrual and reproductive factors in women with Alzheimer's disease in older age

VernacularTitle:女性月经生育因素与老年期阿尔茨海默病的关联
Author: Le XU ¹ ; Kun CHEN ; Junfen LIN ; Tao ZHANG ; Xue GU ; Fudong LI
Author Information

1. 浙江省疾病预防控制中心，杭州　310051
Publication Type:Journal Article
Keywords: Alzheimer's Disease; Estrogen; Menstrual history; Lactation history; Pregnancy history; Surgical and medication history
From: Chinese Journal of Geriatrics 2025;44(1):21-26
CountryChina
Language:Chinese
Abstract: Alzheimer's disease(AD)presents a notable gender disparity in prevalence among elderly individuals, with elderly women being a high-risk group for AD onset.Researches have confirmed the effects of estrogen on the nervous system and cognitive function through in vitro and animal models.Throughout their reproductive years, women undergo various life events such as menarche, menopause, pregnancy, childbirth, miscarriage, relevant surgeries, and medication, all of which can impact their endocrine status and subsequently influence brain function.As a result, there is a growing body of epidemiological evidence investigating the relationship between women's menstrual and reproductive factors and AD.Despite some controversies, this article offers a thorough review of current epidemiological research on the link between different menstrual and fertility factors in women and AD.