Risk factor management for cognitive impairment from a life-course perspective: evidence from the Lancet Commission on Dementia and latest evidence-based findings
10.3760/cma.j.issn.0254-9026.2025.01.001
- VernacularTitle:生命历程视角下认知障碍的风险因素管理：来自柳叶刀痴呆症委员会和最新的循证证据
- Author:
Yating AI
1
;
Yuncui WANG
1
;
Hui HU
1
Author Information
1. 湖北中医药大学，武汉 430065
- Publication Type:Journal Article
- Keywords:
Cognitive impairment;
Risk factors;
Dementia;
Evidence-based
- From:
Chinese Journal of Geriatrics
2025;44(1):1-9
- CountryChina
- Language:Chinese
-
Abstract:
The 2024 update of the Lancet Commission on Dementia synthesizes new research findings since the 2020 report, presenting promising evidence for the prevention, intervention, and care of dementia.This paper explored the key elements of risk factor management as delineated in the report.Currently recognized risk factors associated with cognitive impairment include less education, hearing loss, hypertension, smoking, obesity, depression, physical inactivity, diabetes, excessive alcohol consumption, traumatic brain injury, social isolation, and air pollution.Furthermore, the updated report identifies vision loss and elevated LDL cholesterol as significant contributors to cognitive decline.This article reviewed the most recent evidence-based findings and examines potential underlying mechanisms related to these 14 identified risk factors.It aims to extract strategies for preventing cognitive impairment and proposes a life-course model for managing these risks.Theoretically, addressing these 14 risk factors could avert up to 45% of dementia cases.The paper concluded with forward-looking recommendations for the effective management of cognitive impairment risk factors and outlines directions for future research.
