Advances in resistance mechanisms of carbapenem-resistant Enterobacteriaceae
10.3760/cma.j.cn112309-20250213-00045
- VernacularTitle:碳青霉烯类耐药肠杆菌目细菌的耐药机制研究进展
- Author:
Wenhui JIANG
1
;
Chunyan MO
1
;
Guobing CHEN
1
Author Information
1. 昆明理工大学附属医院/云南省第一人民医院急诊医学科，昆明 650500
- Publication Type:Journal Article
- Keywords:
Carbapenems;
Enterobacter;
Beta-lactam resistance;
Resistance genes
- From:
Chinese Journal of Microbiology and Immunology
2025;45(8):712-716
- CountryChina
- Language:Chinese
-
Abstract:
Carbapenem-resistant Enterobacteriaceae(CRE), one of the most urgent pathogens threatening human health worldwide, has posed a great challenge to clinical treatment. However, the imbalance between the lag in antibiotic research and development and the increase of CRE resistance has led to a "death threat" for patients infected with CRE, and it is urgent to explore new mechanisms of CRE resistance, which is closely related to the role of resistance genes, carbapenemases and efflux pumps. In addition, penicillin-binding protein, biofilms and iron carriers are expected to provide new research ideas to understand the drug resistance mechanism. The aim of this review is to summarize the mechanisms of CRE resistance and to provide new ideas for its treatment.
