Research progress in effects of NSD2 gene on immune function and regulatory mechanism

VernacularTitle:NSD2基因对免疫功能的影响及调控机制的研究进展
Author: Guiyu ZHAO ¹ ; Shujun GAO ; Yuefang LIU
Author Information

1. 扬州大学医学院附属淮安市妇幼保健院产科，淮安　223002
Publication Type:Journal Article
Keywords: B cells; NSD2 gene; Follicular helper T cells; Regulatory T cells; MHCⅠ
From: Chinese Journal of Microbiology and Immunology 2025;45(8):707-711
CountryChina
Language:Chinese
Abstract: Immunodeficiency is one of the main clinical phenotypes of diseases caused by germline loss-of-function variants in the nuclear SET domain-containing protein 2 (NSD2)-coding gene. NSD2 gene plays an important regulatory role in the immune system, but the underlying mechanism has not been fully elucidated. In recent years, great progress has been made regarding the function of NSD2 gene in the immune system including involving in B cell differentiation and development, promoting germinal center B cell activation and antibody production, recruiting regulatory T (Treg) cells to the maternal-fetal interface to induce maternal-fetal immune tolerance, and up-regulating MHCⅠ expression in tumor cells to trigger tumor immunity. This article mainly reviews the research progress in the regulatory function of NSD2 gene in the above immune processes.