Research progress in macrophage metabolic reprogramming caused by Mycobacterium tuberculosis infection
10.3760/cma.j.cn112309-20241031-00370
- VernacularTitle:结核分枝杆菌感染导致巨噬细胞代谢重编程的研究进展
- Author:
Jiaying GUO
1
;
Haohan LIU
1
;
Yu PANG
1
;
Shanshan LI
1
Author Information
1. 首都医科大学附属北京胸科医院(北京市结核病胸部肿瘤研究所)细菌免疫学实验室，耐药结核病研究北京市重点实验室，北京 101149
- Publication Type:Journal Article
- Keywords:
Mycobacterium tuberculosis;
Macrophage;
Metabolism;
Reprogram;
Immune response
- From:
Chinese Journal of Microbiology and Immunology
2025;45(6):535-540
- CountryChina
- Language:Chinese
-
Abstract:
Macrophages play a pivotal role in host defense against Mycobacterium tuberculosis ( Mtb) infection. Their metabolic processes and metabolites are essential for maintaining immune homeostasis, responding to invading pathogens, and orchestrating subsequent immune responses. Therefore, a comprehensive understanding of macrophage metabolic reprogramming during Mtb infection is critical for deciphering the intricate mechanisms underlying the host immune response against tuberculosis. This review summarizes recent advances in how macrophages regulate immune responses through core metabolic pathways, including glucose metabolism, oxidative phosphorylation, lipid metabolism, and amino acid metabolism, in the context of Mtb infection. The insights provided here offer new perspectives and potential strategies for future tuberculosis prevention and targeted therapy.
