Mechanisms of immunosuppression mediated by tumor-associated macrophages on tumor-infiltrating lymphocytes and targeted strategies
10.3760/cma.j.cn112309-20240818-00307
- VernacularTitle:肿瘤相关巨噬细胞介导肿瘤浸润淋巴细胞免疫抑制机制及靶向策略
- Author:
Jingchang LI
1
;
Chuangchuang LI
;
Xiaorui LI
;
Yu SHA
;
Weihong REN
Author Information
1. 河南中医药大学第一附属医院检验科，郑州 450000
- Publication Type:Journal Article
- Keywords:
Tumor-infiltrating lymphocytes;
Immunosuppression;
Tumor-associated macrophages;
Metabolism reprogramming;
Epigenetic remodeling
- From:
Chinese Journal of Microbiology and Immunology
2025;45(11):985-992
- CountryChina
- Language:Chinese
-
Abstract:
Tumor-infiltrating lymphocytes（TILs）are the main anti-tumor immune cells in the tumor microenvironment and play a crucial role in the immunotherapy of solid tumors. However，the presence of an immunosuppressive microenvironment limits their clinical efficacy. As one of the most abundant immunosuppressive cells in the tumor microenvironment，tumor-associated macrophages（TAMs）have a close connection with TILs and play an important role in the immunosuppression on TILs. This review discusses the application of TILs in the field of tumor therapy and their immunosuppressive bottlenecks，elaborates on the role of TAMs in tumor immunosuppression，and summarizes the effects of TAMs on the immune function of TILs through mechanisms such as cytokine secretion，exosome release，metabolic reprogramming，and epigenetic remodeling. In addition，this article also explores the possibility of targeting TAMs as a strategy to improve the anti-tumor efficacy of TILs，aiming to provide new ideas for addressing the immunosuppressive challenges faced by TILs.
